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1

PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8

Okuda, Michiaki, Fujita, Yuki, Hijikuro, Ichiro, Wada, Mei, Uemura, Takuya, Kobayashi, Yukako, Waku, Tomonori, Tanaka, Naoki, Nishimoto, Takaaki, Izumi, Yasuhiko, Kume, Toshiaki, Akaike, Akinori, Taka

Journal:

Journal of Alzheimer's Disease

Année:

2017

Langue:

english

Fichier:

PDF, 691 KB

english, 2017

2

Design, synthesis and evaluation of carbamate-modified (−)-N1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors

Jun Takahashi, Ichiro Hijikuro, Takeshi Kihara, Modachur G. Murugesh, Shinichiro Fuse, Yoshinori Tsumura, Akinori Akaike, Tetsuhiro Niidome, Takashi Takahashi, Hachiro Sugimoto

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 171 KB

english, 2010

3

Design, synthesis, evaluation and QSAR analysis of N1-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors

Jun Takahashi, Ichiro Hijikuro, Takeshi Kihara, Modachur G. Murugesh, Shinichiro Fuse, Ryo Kunimoto, Yoshinori Tsumura, Akinori Akaike, Tetsuhiro Niidome, Yasushi Okuno, Takashi Takahashi, Hachiro Sug

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 179 KB

english, 2010

4

An efficient synthesis of polymer-supported silyl linkers using a di-Grignard reagent

Takayuki Doi, Masahito Yoshida, Ichiro Hijikuro, Takashi Takahashi

Journal:

Tetrahedron Letters

Année:

2004

Langue:

english

Fichier:

PDF, 261 KB

english, 2004

5

Selective capture of 1α,25-(OH)2-previtamin D3 utilizing polymer-supported trialkylsilyl triflate in the synthesis of 1α,25-(OH)2-vitamin D3

Takayuki Doi, Masahito Yoshida, Ichiro Hijikuro, Takashi Takahashi

Journal:

Tetrahedron Letters

Année:

2004

Langue:

english

Fichier:

PDF, 279 KB

english, 2004

6

Parallel Synthesis of a Vitamin D 3 Library in the Solid-Phase

Hijikuro, Ichiro, Doi, Takayuki, Takahashi, Takashi

Journal:

Journal of the American Chemical Society

Année:

2001

Langue:

english

Fichier:

PDF, 171 KB

english, 2001

7

An Efficient Solid-Phase Synthesis of the Vitamin D 3 System

Doi, Takayuki, Hijikuro, Ichiro, Takahashi, Takashi

Journal:

Journal of the American Chemical Society

Année:

1999

Langue:

english

Fichier:

PDF, 53 KB

english, 1999

8

PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo

Okuda, Michiaki, Hijikuro, Ichiro, Fujita, Yuki, Wu, Xiaofeng, Nakayama, Shinichi, Sakata, Yoko, Noguchi, Yuji, Ogo, Makoto, Akasofu, Shigeru, Ito, Yoshimasa, Soeda, Yoshiyuki, Tsuchiya, Nobuhiko, Tan

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 5.64 MB

english, 2015

9

Rapid Library Synthesis of Amphiphiles Based On a Dioxinone Scaffold and Identification of Nonlamellar Liquid Crystals

Fuse, Shinichiro, Nakamura, Kentarou, Mifune, Yuto, Marubayashi, Hironori, Hijikuro, Ichiro, Nojima, Shuichi, Tanaka, Hiroshi, Takahashi, Takashi

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 547 KB

english, 2014

10

A Novel Strategy for the Automated Synthesis of Bis-amides of 1,2-Diamines

Doi, Takayuki, Hijikuro, Ichiro, Takahashi, Takashi

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 90 KB

english, 1999

11

Usefulness of liquid–crystal oral formulations to enhance the bioavailability and skin tissue targeting of p-amino benzoic acid as a model compound

Kadhum, Wesam R., Oshizaka, Takeshi, Ichiro, Hijikuro, Todo, Hiroaki, Sugibayashi, Kenji

Journal:

European Journal of Pharmaceutical Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2016

12

A Novel Chemical Enhancer Approach for Transdermal Drug Delivery with C17-Monoglycerol Ester Liquid Crystal-forming Lipid

Kadhum, Wesam R., Sekiguchi, Shohei, Hijikuro, Ichiro, Todo, Hiroaki, Sugibayashi, Kenji

Journal:

Journal of Oleo Science

Année:

2017

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2017

13

Development and Optimization of Orally and Topically Applied Liquid Crystal Drug Formulations

Kadhum, Wesam R., Hada, Tomoki, Hijikuro, Ichiro, Todo, Hiroaki, Sugibayashi, Kenji

Journal:

Journal of Oleo Science

Année:

2017

Fichier:

PDF, 1011 KB

2017

14

Development and Optimization of Orally and Topically Applied Liquid Crystal Drug Formulations

Kadhum, Wesam R., Hada, Tomoki, Hijikuro, Ichiro, Todo, Hiroaki, Sugibayashi, Kenji

Journal:

Journal of Oleo Science

Année:

2017

Langue:

english

Fichier:

PDF, 1011 KB

english, 2017

15

Antiadhesion effect of the C17 glycerin ester of isoprenoid-type lipid forming a nonlamellar liquid crystal

Murakami, Takahide, Hijikuro, Ichiro, Yamashita, Kota, Tsunoda, Shigeru, Hirai, Kenjiro, Suzuki, Takahisa, Sakai, Yoshiharu, Tabata, Yasuhiko

Journal:

Acta Biomaterialia

Année:

2018

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2018

16

The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol O-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice

Ohshiro, Taichi, Imuta, Satoshi, Hijikuro, Ichiro, Yagyu, Hiroaki, Takahashi, Takashi, Doi, Takayuki, Ishibashi, Shun, Tomoda, Hiroshi

Journal:

Biological & Pharmaceutical Bulletin

Année:

2020

Fichier:

PDF, 868 KB

2020

17

Enhanced nose-to-brain delivery of tranilast using liquid crystal formulations

See, Gerard Lee, Arce, Florencio, Dahlizar, Sabrina, Okada, Akie, Fadli, Muhammad Fikri Bin Mohd, Hijikuro, Ichiro, Itakura, Shoko, Katakura, Masanori, Todo, Hiroaki, Sugibayashi, Kenji

Journal:

Journal of Controlled Release

Année:

2020

Fichier:

PDF, 1.62 MB

2020

18

Synthesis of Resorcinol Derivatives and their Effects on Melanin Production

Tokudome, Yoshihiro, Hoshi, Tsuyoshi, Mori, Sayaka, Hijikuro, Ichiro

Journal:

Année:

2020

Fichier:

PDF, 1.44 MB

2020

19

Topical application of toll-like receptor 3 inhibitors ameliorates chronic allergic skin inflammation in mice

Tamagawa-Mineoka, Risa, Ueta, Mayumi, Arakawa, Yukiyasu, Yasuike, Risa, Nishigaki, Hiromi, Okuno, Yasushi, Hijikuro, Ichiro, Kinoshita, Shigeru, Katoh, Norito

Journal:

Journal of Dermatological Science

Année:

2020

Fichier:

PDF, 844 KB

2020